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Dr. Hoyle received her Ph.D. in Biochemistry from Duke University in 1988. Her postdoctoral research at SmithKline Beecham Pharmaceuticals involved studying the envelope and rev proteins of HIV under the direction of Dr. Martin Rosenberg. In 1991, she was appointed as a Senior Research Biochemist in the Department of Cancer Research at Merck Research Laboratories where she studied the retinoblastoma protein pRb and its interactions with transcription factor E2F and the E7 protein of HPV.

Dr. Hoyle joined the Department of Cell and Molecular Biology at Tulane University in 1994 as an instructor in Genetics courses. Since then, she has also taught for the Department of Biochemistry at Tulane Health Sciences Center as an instructor for a graduate student laboratory course, Methods in Biochemistry and Molecular Biology. Dr. Hoyle joined the Human Genetics Program as an instructor for Human Molecular Genetics in 2001.

EDUCATION:

August, 1979-December, 1982 -
B. S. Biochemistry, Louisiana State University, Baton Rouge, LA.

January, 1983-October, 1988 -
Ph.D. Biochemistry, Duke University, Durham, NC.

RESEARCH AND TEACHING EXPERIENCE:

Summer, 1982 Undergraduate Research Internship with Dr. R.C. Montelaro, Dept. of Biochemistry, Louisiana State University, Baton Rouge, LA.

January, 1983 -October, 1988 NIH and NSF Predoctoral Trainee with Dr. D.A. Steege,
Dept. of Biochemistry, Duke University Medical Center, Durham, NC.

November, 1988 -October, 1990 NIH Postdoctoral Fellow under the direction of Dr. Martin Rosenberg, Vice President,Biopharmaceutical Research and Development, SmithKline Beecham Pharmaceuticals, King of Prussia, PA.

October, 1990 -February, 1991 Associate Senior Investigator, Dept. of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, PA.

March, 1991- October, 1993 Senior Research Biochemist, Dept. of Cancer Research, Merck Research Laboratories, West Point, PA.

August 1994 - July 1997 Adjunct Assistant Professor, Dept. of Biological Sciences, Univ. of New Orleans, New Orleans, LA. Courses taught: Biochemistry and Molecular Biology Lab; Microbiology.

August 1994 - present Instructor, Dept. of Cell and Molecular Biology and University College, Tulane University, New Orleans, LA. Courses taught: Genetics; Heredity and Society.

December 1995 -May 1997 Associate Scientist, Dept. of Pathology, Tulane University Health Sciences Center, New Orleans, LA.

November 1997 -Dec 2001 Adjunct Instructor, Dept. of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA. Course taught: Biochemistry & Molecular Biology Lab

PUBLICATIONS:

Montelaro, R. C., M. West, and M. Ivey (l983) Effects of common radioiodination procedures on the binding of glycoproteins to immobilized lectins. Biochem. Biophys. Res. Comm. 110:103-107.

Blumer, K. J., K. C. Cone, M. R. Ivey, R. J. Matteson, and D. A. Steege (1986) Functionally distinct classes of prokaryotic translational initiation sites. In Contemporary Themes in Biochemistry: Proceedings of the 4th Federation of Asian and Oceanian Biochemists Congress (Kon, O. L., M. C.-M. Chung, P. L. H. Hwang, S.-F. Leong, K. H. Loke, P. Thiyagarajah, and P. T.-H. Wong, eds.), pp. 272-273, Cambridge University Press, Cambridge.

Blumer, K. J., M. R. Ivey, and D. A. Steege (1987) Translational control of phage f1 gene expression by differential activities of the gene V, VII, IX, and VIII initiation sites. J. Mol. Biol. 197:439-451.

Ivey-Hoyle, M. and D. A. Steege (1989) Translation of phage f1 gene VII occurs from an inherently defective initiation site made functional by coupling. J. Mol. Biol. 208:233-244.

Steege, D. A. and M. Ivey-Hoyle (1990) The phage f1 gene VII start site and its mutants reveal that translational coupling can confer function to inherently inactive initiation sites. In Post-transcriptional control of Gene Expression. NATO/ASI Series, Vol. H49, pages 197-206, Springer-Verlag, Heidelberg.

Ivey-Hoyle, M. and M. Rosenberg (1990) Rev-dependent expression of HIV-1 gp160 in Drosophila melanogaster cells. Mol. Cell. Biol. 10:6152-6159.

Ivey-Hoyle, M., J. S. Culp, M. A. Chaikin, B. D. Hellmig, T. J. Matthews, R. W. Sweet and M. Rosenberg (1991) Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4. Proc. Natl. Acad. Sci. USA 88:512-516.

Ivey-Hoyle, M. and M. Rosenberg (1991) Expression of HIV-1 gp160 in Drosophila: Role of N-terminal amino acids in cell-association of gp120. J. Virol., 65:2682-2685.

Brighty, D. A., M. Rosenberg, I. S. Y. Chen and M. Ivey-Hoyle (1991) Envelope proteins from clinical isolates of human immunodeficiency virus type 1 that are refractory to neutralization by soluble CD4 possess high affinity for the CD4 receptor. Proc. Natl. Acad. Sci. USA, 88:7802-7805.

Angelichio, M. L., J. A. Beck, H. Johansen and M. Ivey-Hoyle (1991) Comparison of several promoters and polyadenylation signals for use in heterologous gene expression in cultured Drosophila cells. Nucleic Acids Research, 19:5037-5043.

Ivey-Hoyle, M. (1991) Recombinant gene expression in cultured Drosophila melanogaster cells. Current Opinion in Biotechnology, 2:704-707.

Ivey-Hoyle, M. and D. A. Steege (1992) Mutational analysis of an inherently defective translation initiation site. J. Mol. Biol., 224:1039-1054.

Haskell, K. M., G. A. Vuocolo, D. Defeo-Jones, R. E. Jones and M. Ivey-Hoyle (1993) Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product. J. Gen. Virol., 74:115-119.

Defeo-Jones, D., G. A. Vuocolo, K. M. Haskell, M. G. Hanobik, D. M. Kiefer, E. M. McAvoy, M. Ivey-Hoyle, J. L. Brandsma, A. Oliff, and R. E. Jones (1993) Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts. J. Virol., 67:716-725.

Huber, H. E., G. Edwards, P. J. Goodhart, D. R. Patrick, P. S. Huang, M. Ivey-Hoyle, S. F. Barnett, A. Oliff, and D. C. Heimbrook (1993) Transcription factor E2F binds DNA as a heterodimer. Proc. Natl. Acad. Sci. USA, 90:3525-3529.

Ivey-Hoyle, M., R. Conroy, H. E. Huber, P. J. Goodhart, A. Oliff, and D. C. Heimbrook (1993) Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell. Biol., 13: 7802-7812.

PATENTS:

Ivey-Hoyle, M. and M. Rosenberg (1990) Enhanced expression of viral proteins in Drosophila cells.

Ivey-Hoyle, M., D. C. Heimbrook, and A. I. Oliff (1993) E2F-2, A novel mammalian transcription factor.

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Hayward Genetics Center-Human Genetics Program
Tulane University School of Medicine
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New Orleans, LA 70112
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