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1981 - Present Journal
publications
Ehrlich M, Jackson K, Tsumagari K, Camaño P,
Lemmers RJ. Hybridization analysis of D4Z4 repeat
arrays linked to FSHD. Chromosoma. 2007 Apr;116(2):107-16. Epub 2006 Nov 28.
Alexiadis V, Ballestas ME, Sanchez C, Winokur S,
Vedanarayanan V, Warren M, Ehrlich M.RNAPol-ChIP
analysis of transcription from FSHD-linked tandem repeats and satellite DNA.
Biochim Biophys Acta. 2007 Jan;1769(1):29-40. Epub 2006 Nov 22.
Ehrlich M, Woods CB, Yu MC, Dubeau L, Yang F, Campan M,
Weisenberger DJ, Long T, Youn B, Fiala ES, Laird PW. Quantitative
analysis of associations between DNA hypermethylation, hypomethylation, and
DNMT RNA levels in ovarian tumors. Oncogene. 2006 Apr 27;25(18):2636-45.
Ehrlich M, Jackson K, Weemaes C. Immunodeficiency,
centromeric region instability, facial anomalies syndrome (ICF). Orphanet J
Rare Dis. 2006 Mar 1;1:2.
Ehrlich M. Cancer-linked DNA
hypomethylation and its relationship to hypermethylation. Curr Top Microbiol
Immunol. 2006;310:251-74. Review.
Nishiyama R, Qi L, Lacey M, Ehrlich M. Both
hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in
cancer. Mol Cancer Res. 2005 Nov;3(11):617-26.
Ehrlich, M. The controversial denouement of
vertebrate DNA methylation research. Biochemistry
(Mosc). May;70(5):568-75. (2005)
Gisselsson, D., Shao, C., Tuck-Muller, C., Sogorovic, S.,
Palsson, E., Smeets, D. and Ehrlich, M. Interphase chromosomal
abnormalities and mitotic missegregation of hypomethylated sequences in ICF
syndrome cells.Chromosoma. Jul;114(2):118-26.
(2005)
Nishiyama, R., Qu, L., Tsumagari, K., Dubeau, L.,
Weissbecker, K., Champagne, M., Sikka, S., Nagai, H. and Ehrlich,
M.A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated
in others. Cancer Biol Ther.
Apr 21;4(4) (2005)
Grunau, C., Sanchez, C., Ehrlich, M., van der Bruggen, P.,
Hindermann, W., Rodriguez, C., Krieger, S., Dubeau, L., Fiala, E., & De
Sario, A. Frequent DNA hypomethylation of human
juxtacentromeric BAGE loci in cancer. Genes Chromosomes Cancer.
May;43(1):11-24. (2005)
Jackson, K., Yu, M., Fiala, E., Youn, B., Muller, H.M.,
Widschwendter, M. and Ehrlich, M. DNA hypomethylation is prevalent
even in low-grade breast cancers. Cancer
Biol Ther. Dec;3(12):1225-31 (2004)
Jiang, G., Sanchez, C., Yang, F. and Ehrlich, M.,
Histone modification in constitutive heterochromatin versus unexpressed
euchromatin in human cells. J. Cell. Biochem.93: 286-300 (2004)
Widschwendter, M., Jiang, G., Woods, C., Muller, H.M.,
Fiegl, H., Goebel, G., Marth, C., Holzner, E.M., Zeimet, A.G., Laird, P.W.
and Ehrlich, M., DNA hypomethylation and ovarian cancer
biology. Cancer Res.64: 4472-4480 (2004).
Yang, F., Shao, C., Vedanarayanan, V. and Ehrlich, M.
(2004) Cytogenetic and Immuno-FISH analysis of the 4q subtelomeric region,
which is associated with facioscapulohumeral muscular dystrophy. Chromosoma,
112:350-359.
Jiang, G., Yang, F., Van Overveld, P.G., Vedanarayanan,
V., Van Der Maarel, S. and Ehrlich, M. Testing the
position-effect variegation hypothesis for facioscapulohumeral muscular
dystrophy by analysis of histone modification and gene expression in
subtelomeric 4q, Hum. Mol. Genet. 12: 2909-2921 (2003).
Ehrlich, M. (2003) The ICF syndrome, a DNA
methyltransferase 3B deficiency and immunodeficiency disease. Clin. Immunol.,
109: 17-28
Ehrlich M., Hopkins N., Jiang G., Dome J., Yu M., Woods
C., Tomlinson G., Chintagumpala M., Champagne M., Diller L., Parham D., &
Sawyer J., Satellite DNA hypomethylation in karyotyped Wilms
tumors, Cancer Genet. Cytogen. 141: 97-105 (2003).
Tsien F., Youn, B., Fiala E., Laird P., Long, T.,
Weissbecker K.,& Ehrlich M., Prolonged culture of
chorionic villus cells yields ICF syndrome-like chromatin decondensation and
rearrangements, Cytogen. Genome Res. 98: 13-21 (2003).
Ehrlich, M. Expression of various genes is
controlled by DNA methylation during mammalian development, J. Cell. Biochem.
88:899-910 (2003).
Jiang, G. Fan Y., Li, M., Weissbecker, K., Price, S., Kim,
K.C., LaRussa, V., Safah, H. and Ehrlich, M. Imatinib (STI571)
provides only limited selectivity for CML cells and treatment might be
complicated by silent BCR-ABL genes, Cancer Biol. Ther. 2:103-118 (2003).
Ehrlich M. DNA hypomethylation, cancer, the
ICF syndrome, and chromosomal rearrangements, J. Nutrition 132: 24424S-2429S
(2002).
Ehrlich, M. DNA methylation in cancer: too
much, but also too little, Oncogene 21: 5400-5413 (2002).
Ehrlich M., Jiang G., Fiala E, Dome J., Yu M., Long
T.,Youn B., Sohn O., Widschwendter M., Tomlinson G., Chintagumpala M.,
Champagne M., Parham D., Liang G., Malik, K., & Laird P.,
Hypomethylation and hypermethylation of DNA in Wilms tumors, Oncogene 21:
6694-6702 (2002).
Ehrlich M.,Tsien F., Herrera D., Blackman V., Roggenbuck
J., & Tuck-Muller C., High frequencies of ICF
syndrome-like pericentromeric heterochromatin decondensation and breakage in
chromosome 1 seen in a chorionic villus sample, J. Med. Gen.38: 882-884 (2001).
Tsien F., Sun B., Hopkins N., Vedanarayanan V., Figlewicz
F., Winokur S., & Ehrlich M., Methylation of the FSHD
syndrome-linked subtelomeric repeat in normal and FSHD cells cultures and
tissues, Molec. Gen. Metab. 74: 1-10 (2001).
Sun B., Jiang G., Zaydin M., LaRussa V., Safah H., and
Ehrlich M. ABL1 promoter methylation can exist independently
of BCR-ABL transcription in chronic myeloid leukemia hematopoietic
progenitors, Cancer Res. 61: 6931-6937 (2001).
Ehrlich M., Buchanan K., Tsien F., Jiang G., Sun B.,
Uicker W., Weemaes C., Smeets D., Sperling K., Belohradsky, B.,Tommerup N.,
Misek D., Kuick R., & Hanash S., DNA methyltransferase 3B
mutations linked to the ICF Syndrome cause dysregulation of lymphocyte
migration, activation, and survival genes, Hum. Molec. Gen. 10: 2917-2931
(2001).
Narayan, A., Tuck-Muller, C., Smeets, D., Ehrlich, M.
Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in
cell lines from patients with the ICF chromosome instability syndrome,
Mutation Res., 456: 1-15 (2000)
Tuck-Muller, C., Narayan, A., Tsien, F., Smeets, D.F.C.M.,
Sawyer, J., Fiala, E.S., Sohn, O.S., & Ehrlich, M. DNA
hypomethylation and unusual chromosome instability in cell lines from ICF
syndrome patients. Cytogen. Cell Gen. 89: 121-128 (2000).
M. Ehrlich, DNA Hypomethylation and Cancer,
M. Ehrlich ed., In DNA Alterations In Cancer: Genetic and Epigenetic Changes,
BioTechniques Books, Eaton Publishers, Boston, MA (2000).
Kondo T, Bobek MP, Kuick R, Lamb B, Zhu X, Narayan A,
Bourc'his D, Viegas-Pequignot E, Ehrlich M, Hanash SM. Whole-genome
methylation scan in ICF syndrome: hypomethylation of non-satellite DNA
repeats D4Z4 and NBL2. Hum Mol Genet. 2000 Mar 1;9(4):597-604.
Sengupta PK, Ehrlich M, Smith BD. A
methylation-responsive MDBP/RFX site is in the first exon of the collagen
alpha2(I) promoter. J Biol Chem. 1999 Dec 17;274(51):36649-55.
Qu GZ, Ehrlich M. Demethylation and
expression of methylated plasmid DNA stably transfected into HeLa cells.
Nucleic Acids Res. 1999 Jun 1;27(11):2332-8.
Qu G, Dubeau L, Narayan A, Yu MC, Ehrlich M.Satellite
DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial
tumors of different malignant potential.
Mutat Res. 1999 Jan 25;423(1-2):91-101.
Qu GZ, Grundy PE, Narayan A, Ehrlich M.Frequent
hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and
16. Cancer Genet Cytogenet. 1999 Feb;109(1):34-9.
Narayan A, Ji W, Zhang XY, Marrogi A, Graff JR, Baylin SB,
Ehrlich M. Hypomethylation of pericentromeric DNA in breast
adenocarcinomas.Int J Cancer. 1998 Sep 11;77(6):833-8.
Samac S, Rice JC, Ehrlich M. Analysis of
methylation in the 5' region of the human alpha-galactosidase A gene
containing a binding site for methylated DNA-binding protein/RFX1-4.
Biol Chem. 1998 Apr-May;379(4-5):541-4.
M. Ehrlich
& X-Y. Zhang, Detection and Quantitation of Low Numbers of Chromosomes
Containing bcl-2 Oncogene Translocations Using Semi-Nested PCR, In PCR
Techniques: Quantitative PCR., pp. 297-310, J.W. Larrick, ed., Eaton Pub.,
N.Y. (1997).
Hernandez R, Frady A, Zhang XY, Varela M, Ehrlich M.
Preferential induction of chromosome 1 multibranched figures and whole-arm
deletions in a human pro-B cell line treated with 5-azacytidine or
5-azadeoxycytidine. Cytogenet Cell Genet. 1997;76(3-4):196-201.
Ji W, Hernandez R, Zhang XY, Qu GZ, Frady A, Varela M,
Ehrlich M. DNA demethylation and pericentromeric
rearrangements of chromosome 1.
Mutat Res. 1997 Sep 5;379(1):33-41.
Zhang XY, Safah H, Mudad R, Maher E, Krause J, Miller A,
Ehrlich M. Frequency of BCL-2/J(H) translocations in
peripheral blood of follicular lymphoma patients.
Am J Hematol. 1997 Aug;55(4):205-7.
Saifudeen Z, Desnick RJ, Ehrlich M. A
mutation in the 5' untranslated region of the human alpha-galactosidase A
gene in high-activity variants inhibits specific protein binding.
FEBS Lett. 1995 Sep 4;371(2):181-4.
Warshamana GS, Qu GZ, Zhang XY, Ji W, Ehrlich M. Reporter
gene expression upon stable transfection when only a TATA box or a TATA box
plus Sp1 sites are present 5' to the gene.
DNA Cell Biol. 1995 Aug;14(8):709-17.
Zhang XY, Ni YS, Saifudeen Z, Asiedu CK, Supakar PC,
Ehrlich M.Increasing binding of a transcription factor
immediately downstream of the cap site of a cytomegalovirus gene represses
expression. Nucleic Acids Res. 1995 Aug 11;23(15):3026-33.
Ji W, Qu GZ, Ye P, Zhang XY, Halabi S, Ehrlich M. Frequent
detection of bcl-2/JH translocations in human blood and organ samples by a quantitative
polymerase chain reaction assay. Cancer Res. 1995 Jul 1;55(13):2876-82.
Ji W, Zhang XY, Warshamana GS, Qu GZ, Ehrlich
M. Effect of internal direct and inverted Alu repeat sequences
on PCR. PCR Methods Appl. 1994 Oct;4(2):109-16.
Asiedu CK, Scotto L, Assoian RK, Ehrlich M. Binding
of AP-1/CREB proteins and of MDBP to contiguous sites downstream of the human
TGF-beta 1 gene. Biochim Biophys Acta. 1994 Sep 13;1219(1):55-63.
Zhang XY, Ehrlich M Detection and
quantitation of low numbers of chromosomes containing bcl-2 oncogene
translocations using semi-nested PCR.
Biotechniques 1994 Mar;16(3):502-7
Zhang XY, Jabrane-Ferrat N, Asiedu CK, Samac S,
Peterlin BM, Ehrlich M. The major histocompatibility complex
class II promoter-binding protein RFX (NF-X) is a methylated DNA-binding protein.
Mol Cell Biol. 1993 Nov;13(11):6810-8.
M. Ehrlich
& K. Ehrlich, Effects of DNA Methylation on the Binding of Vertebrate and
Plant Proteins to DNA, In DNA Methylation: Biological Significance,
pp.145-168, J.P. Jost and H.P. Saluz, eds., Birkhauser Verlag, Boston (1993).
Inamdar NM, Zhang XY, Brough CL, Gardiner WE,
Bisaro DM, Ehrlich M. Transfection of heteroduplexes
containing uracil.guanine or thymine.guanine mispairs into plant cells.
Plant Mol Biol. 1992 Oct;20(1):123-31.
Ehrlich KC, Cary JW, Ehrlich M. A broad
bean cDNA clone encoding a DNA-binding protein resembling mammalian CREB in
its sequence specificity and DNA methylation sensitivity.
Gene. 1992 Aug 15;117(2):169-78.
Zhang XY, Asiedu CK, Supakar PC, Ehrlich M Increasing
the activity of affinity-purified DNA-binding proteins by adding high
concentrations of nonspecific proteins.
Anal Biochem 1992 Mar;201(2):366-74
Brough CL, Gardiner WE, Inamdar NM, Zhang XY, Ehrlich M,
Bisaro DM. DNA methylation inhibits propagation of tomato
golden mosaic virus DNA in transfected protoplasts.
Plant Mol Biol. 1992 Feb;18(4):703-12.
Asiedu CK, Supakar PC, Ehrlich M. End-filling
of an oligonucleotide duplex containing an MDBP site in the human HSP70
promoter inhibits protein-DNA complex formation.
Biochem Biophys Res Commun. 1991 Aug 15;178(3):927-33.
Inamdar NM, Ehrlich KC, Ehrlich M. CpG
methylation inhibits binding of several sequence-specific DNA-binding
proteins from pea, wheat, soybean and cauliflower.
Plant Mol Biol. 1991 Jul;17(1):111-23.
Zhang XY, Inamdar NM, Supakar PC, Wu K, Ehrlich KC,
Ehrlich M Three MDBP sites in the immediate-early
enhancer-promoter region of human cytomegalovirus. Virology 1991
Jun;182(2):865-9
M.
Ehrlich & X-Y. Zhang, Naturally Occurring Modified Nucleosides in DNA. In
Chromatography and Modification of Nucleosides, pp. B327-B362, C.W. Gehrke
& K.C.T. Kuo, eds., Elsevier, Amsterdam (1990).
M. Ehrlich, X-Y. Zhang, C.K. Asiedu, R. Khan, & P.C. Supakar, Methylated
DNA-Binding Protein from Mammalian Cells. In Nucleic Acid Methylation, pp.
351-365, G.A. Clawson, D.B. Willis, A. Weissbach, & P. Jones, eds.,
Wiley-Liss, N.Y. (1990).
Zhang XY, Asiedu CK, Supakar PC, Khan R, Ehrlich KC,
Ehrlich M. Binding sites in mammalian genes and viral gene
regulatory regions recognized by methylated DNA-binding protein. Nucleic
Acids Res. 1990 Nov 11;18(21):6253-60.
Zhang XY, Supakar PC, Wu KZ, Ehrlich KC, Ehrlich M. An
MDBP site in the first intron of the human c-myc gene. Cancer Res. 1990 Nov
1;50(21):6865-9.
Ehrlich KC, Ehrlich M. Highly repeated
sites in the apolipoprotein(a) gene recognized by methylated DNA-binding
protein, a sequence-specific DNA-binding protein.
Mol Cell Biol. 1990 Sep;10(9):4957-60.
Ehrlich M, Zhang XY, Inamdar NM. Spontaneous deamination of cytosine and
5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues
with cytosine residues.Mutat Res. 1990 May;238(3):277-86.
Zhang DL, Ehrlich KC, Supakar PC, Ehrlich M. A
plant DNA-binding protein that recognizes 5-methylcytosine residues. Mol Cell
Biol. 1989 Mar;9(3):1351-6.
Supakar PC, Weist D, Zhang DL, Inamdar N, Zhang
XY, Khan R, Ehrlich KC, Ehrlich M. Methylated DNA-binding
protein is present in various mammalian cell types.
Nucleic Acids Res. 1988 Aug 25;16(16):8029-44.
Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M. Reduced
genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res. 1988
Mar 1;48(5):1159-61.
Zhang XY, Loflin PT, Gehrke CW, Andrews PA,
Ehrlich M. Hypermethylation of human DNA sequences in
embryonal carcinoma cells and somatic tissues but not in sperm.
Nucleic Acids Res. 1987 Nov 25;15(22):9429-49.
Zhang XY, Ehrlich KC, Wang RY, Ehrlich M. Effect
of site-specific DNA methylation and mutagenesis on recognition by methylated
DNA-binding protein from human placenta.
Nucleic Acids Res. 1986 Nov 11;14(21):8387-97.
Wang RY, Zhang XY, Ehrlich M. A human
DNA-binding protein is methylation-specific and sequence-specific. Nucleic
Acids Res. 1986 Feb 25;14(4):1599-614.
Zhang XY, Wang RY, Ehrlich M. Human
DNA sequences exhibiting gamete-specific hypomethylation. Nucleic Acids Res.
1985 Jul 11;13(13):4837-51.
Feinstein SI, Miller DA, Ehrlich M, Gehrke CW, Eden LB,
Miller OJ. DNA methylation is not increased in mouse-human
somatic cell hybrids. Biochim Biophys Acta. 1985 Apr 19;824(4):336-40.
Ehrlich M, Gama-Sosa MA, Carreira LH, Ljungdahl LG, Kuo
KC, Gehrke CW. DNA methylation in thermophilic bacteria:
N4-methylcytosine, 5-methylcytosine, and N6-methyladenine.Nucleic Acids Res.
1985 Feb 25;13(4):1399-412.
Huang LH, Wang R, Gama-Sosa MA, Shenoy S,
Ehrlich M. A protein from human placental nuclei binds
preferentially to 5-methylcytosine-rich DNA. Nature. 1984 Mar
15-21;308(5956):293-5.
Gama-Sosa MA, Slagel VA, Trewyn RW, Oxenhandler R, Kuo KC,
Gehrke CW, Ehrlich M The 5-methylcytosine content of DNA from
human tumors. Nucleic Acids Res. 1983 Oct 11;11(19):6883-94.
Gama-Sosa MA, Midgett RM, Slagel VA, Githens S, Kuo KC,
Gehrke CW, Ehrlich M. Tissue-specific differences in DNA
methylation in various mammals. Biochim Biophys Acta. 1983 Jun
24;740(2):212-9.
Ehrlich M, Gama-Sosa MA, Huang LH, Midgett RM, Kuo KC,
McCune RA, Gehrke C. Amount and distribution of
5-methylcytosine in human DNA from different types of tissues of cells.
Nucleic Acids Res. 1982 Apr 24;10(8):2709-21.
Ehrlich M, Wang RY. 5-Methylcytosine
in eukaryotic DNA. Science. 1981 Jun 19;212(4501):1350-7.
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