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Hiroyuki Kobori, M.D., Ph.D.

(Tubular renin-angiotensin system)

Assistant Professor
M.D.: 1990, Keio University, Tokyo, Japan
Ph.D.: 1998, Keio University, Tokyo, Japan
Post Doc: 1998-2001, Tulane University

The concomitant increases in renal angiotensinogen protein and angiotensinogen mRNA that occurs during chronic angiotensin II infusions provides a firm foundation for the hypothesis that enhanced intrarenal angiotensinogen production contributes to the increased intrarenal angiotensin II levels and the altered renal function that leads to the progressive development of hypertension in angiotensin II-dependent hypertensive rats. However, the mechanisms responsible for the ability of moderate increases in circulating angiotensin II to cause progressive increases in arterial pressure remain incompletely understood. The central hypothesis of my project is that angiotensin II-dependent hypertension is characterized by augmented proximal tubular angiotensinogen secretion leading to increased distal nephron spillover of angiotensinogen coupled with stimulation of distal tubular renin formation leading to increased distal formation of angiotensin II. Furthermore, the distal nephron spillover of angiotensinogen is reflected by increased urinary angiotensinogen excretion rates, which can be used as an index of intrarenal angiotensin II activity.

Related ongoing collaborations:
Intrarenal renin-angiotensin system in tubular cell apoptosis in focal glomerulosclerosis; Dr. Singhal, Long Island Jewish Medical Center, New Hyde Park, NY

Intrarenal renin-angiotensin system in radiation nephropathy; Dr. Cohen, Medical College of Wisconsin, Milwaukee, WI

Urinary excretion of angiotensinogen as a specific marker of intrarenal renin-angiotensin system status in hypertensive patients
Drs. Alper and Hamm, Tulane University

Development of a new assay system for human angiotensinogen: SPI-Bio, France

Intrarenal renin-angiotensin system in chronic glomerular nephritis; Dr. Shoji, Osaka Prefectural General Hospital, Osaka, Japan

Intrarenal renin-angiotensin system and oxidative stress in salt-sensitive hypertension; Dr. Nishiyama, Kagawa Medical University, Kagawa, Japan

Intrarenal renin-angiotensin system in diabetic nephropathy; Dr. Nishiyama, Kagawa Medical University, Kagawa, Japan

Recent Publications:

A PubMed listing of research publications for Hiroyuki Kobori, M.D., Ph.D.

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