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Electrophysiology and Synaptic Transmission
GPSO-758
SPRING SEMESTER
Electrophysiology and Synaptic Transmission is a 3 credit intermediate
level graduate course designed as a sequel to Graduate Neuroscience
to provide the general student with a broad base of knowledge of cellular
neurophysiology. Prerequisites for the course are Graduate Neuroscience
or Physiology 601. The course has an emphasis on ionic channel aspects
of electrophysiology and covers passive electrical properties of cell
membranes, the experiments of Hodgkin and Huxley, molecular biology
and permeation of ion channels. Synaptic transmission is covered in
terms of both ion channels, transmitter release and synaptic integration.
Computer simulations of ion channel and cell electrical behavior are
used as an aid for students to gain practice with basic concepts.
Lecture list
|
|
ORGANIZATIONAL MEETING - Handout Assignments (Rm 4024) |
| Lecture 1 |
Passive Electrical Properties of Cell Membranes (Kreisman) |
| Lecture 2 |
Hodgkin and Huxley Experiments I (Elmslie) |
| Lecture 3 |
Hodgkin and Huxley Experiments II (Elmslie) |
| Lecture 4 |
Ion Permeation (Elmslie) |
| Lecture 5 |
Ion Effects on Excitability (Kreisman) |
| Lecture 6 |
Computer Laboratory: Voltage-Clamp Simulation (Staff) |
|
|
EXAM 1 |
| Lecture 7 |
Potassium Channels (Schofield) |
| Lecture 8 |
Epithelial Transport (Awayda) |
| Lecture 9 |
Ion Channels and Transport (Awayda) |
| Lecture 8 |
Voltage-Gated Calcium Channels (Elmslie) |
| Lecture 9 |
Ion channel modulation I (Elmslie) |
| Lecture 10 |
Ion channel modulation II (Elmslie) |
| Lecture 12 |
Molecular Biology of Ion Channels (Elmslie) |
|
|
EXAM 2 |
| Lecture 13 |
Non Voltage-Gated Calcium Channels (Schofield) |
| Lecture 14 |
Transmitter Release (Schofield) |
| Lecture 15 |
Neuromuscular Junction and other Synapses (Schofield) |
| Lecture 16 |
Receptor-Operated Channels (Schofield) |
| Lecture 17 |
Electrical Synapses and Synaptic Integration (Magee) |
|
|
FINAL EXAMINATION |
Notes:
- Minimum enrollement 4 students.
This course can be taken concurrently with Graduate Neuroscience. The
Physiology Department also has more advanced courses available for those
wishing to specialize in this area.
- Required Text: B. Hille, Ionic Channels of Excitable Membranes (3Rd ed.) Sinauer Press, Sunderland, MA, 1992.
1430 Tulane Ave., New Orleans, LA 70112
504-988-5251; Fax # 504-988-2675