Experimental
Physiology
GPSO
606
Course Director: Dr.
Majid
Instructors: Drs.
Majid , Swanson, Johnson, Elmslie, Awada
Goals
and Objectives: The course will focus on the basic
functions of cardiovascular, respiratory, renal, skeletal muscle and cellular
transport systems using anesthetized animal models (pigs, rats, frogs
etc) as well as human volunteers. The student will practice some basic
simple surgical procedures in anesthetized animals and will formulate
experimental design and research ideas aimed at strengthening the foundations
of their medical, surgical and research training.
Students
in this course will:
1) learn fundamental regulatory mechanisms of some basic organs in a living
system.
2) practice simple surgical procedures on a living animal.
3) acquire basic experience in conducting biological research in-vivo
using animal models.
4) consider the ethics of using animals in research.
Methods of Instruction:
The course will consist of laboratory exercises, research orientation
and group discussions. Students will work in a group under the guidance
of the instructor.
Requirements: Medical/
graduate students who have taken/will take the Human Physiology course.
Length of course: 16 weeks
Class hours per week: Four
hours (Friday, 1pm to 5pm)
Grading: Medical students
will receive a grade of Satisfactory or Unsatisfactory to be determined
on the basis of attendance and participation. Graduate students will receive
a letter grade. Attendance is mandatory. Excused absences may be granted
only by the Dean, Department Chair or instructors.
List of Topics
Session |
Topic
|
Instructor
|
1 |
Introductory Session:
-Physiological measuring techniques; Assessment of Pressure-volume
and pressure-flow relationship;
- General principles of the use of animals in experiments in physiology:
(Introduction to surgical tools, principles of surgery, rules and
discipline in animal experimentation)
|
Drs. Swanson/Majid
|
2 |
Experiment in Frog: Mechanisms
of Na+ reabsorption by tight-epithelia. |
Dr. Awayda |
3 |
- Experiment in Frog:
Neuro-muscular function. |
Dr. Elmslie |
4 |
- Experiment in rats:
Langendorf Heart Preparation |
Drs. Robert Johnson/
Fruzsina Johnson |
5 |
Experiment in pig: Cardiovascular
regulation. |
Drs. Majid/Swanson |
6 |
Discussion on the experimental
findings in cardiovascular regulation |
Dr. Majid |
7 |
Quantitative cardiovascular
physiology (QCP)
(Computer simulation of the circulatory system)
Design and conduct experiments on QCP |
Drs. Swanson /Majid |
8 |
Experiment in pig: Control
of ventilation. |
Drs. Swanson/Majid |
9 |
Discussion on the experimental
findings in control of ventilation. |
Dr. Swanson |
10 |
Experiment in pig: Renal
excretory function. |
Drs. Majid/Swanson |
11 |
Discussion on the experimental
findings in renal excretory function. |
Dr. Majid |
12 |
Regulation of water, electrolytes
and pH by the kidneys in human |
Drs. Majid/Swanson |
13 |
Experiments on Rabbit
Smooth muscle Prep: GI experiments |
Dr. Solange Abdournur |
14 |
Reproductive Physiology:
Lab experiment |
Dr. Fruzsina Johnson |
15 |
Reproductive Physiology
– Field trip to Primate Research Center |
Dr. Harrison |
16 |
Final evaluation/wrap-up
session |
All Instructors |
|