One month after visiting un-charted caves, a 32 year old archeologist developes progressive malaise, headaches, fever , convulsions and hydrophobia. What morphological changes might you expect in this patient’s brain at autopsy?

1. eosinophilic cytoplasmic inclusions in pyramidal neurons of thr hippocampus
2. peri-vascular lymphocytosis in the brain stem
3. Negri bodies in Purkinje cells of the cerebellum
4. All of the above