Crawford, Byron E.

CNS Tumors Quiz

1). Differentiation of a low grade astrocytoma from a glioblastoma multiforme is based on:

    1. absence of necrosis in a glioblastoma multiforme
    2. presence of necrosis in a glioblastoma multiforme
    3. presence of necrosis in a well differentiated astrocytoma
    4. presence of vascular proliferation in a well differentiated astrocytoma
    5. absence of vascular proliferation in a glioblastoma multiforme

2). The most common brain tumor in adults is:

    1. low grade astrocytoma
    2. meningioma
    3. metastatic carcinoma
    4. glioblastoma multiforme
    5. oligodendroglioma

3). The following tumor(s) retain cellular features of undifferentiated primitive neuroectodermal cells:

    1. medulloblastoma
    2. oligodendroglioma
    3. ganglioneuroma
    4. pilocytic astrocytoma
    5. pleomorphic xanthoastrocytoma

4). The following tumors occur commonly in the ventricles and in the filum terminale of the spinal cord:

    1. pilocytic astrocytoma
    2. hemangioblastoma
    3. oligodendroglioma
    4. medulloblastoma
    5. ependymoma

5). The following is the most common CNS neoplasm in immunocompromised patients:

    1. Kaposi’s sarcoma
    2. meningeal carcinomatosis
    3. primary CNS lymphoma
    4. medulloblastoma
    5. pleomorphic xanthoastrocytoma

6). A brain tumor which sometimes contains psammoma bodies and progesterone receptors is:

    1. hemangioblastoma
    2. meningioma
    3. germ cell tumor
    4. primary brain lymphoma
    5. pineoblastoma

7). The following CNS tumor is commonly cystic, histologically contains Rosenthal fibers and typically occurs in children and young adults:

    1. hemangioblastoma
    2. medulloblastoma
    3. pleomorphic xanthoastrocytoma
    4. pilocytic astrocytoma
    5. germ cell tumor

8). The following list of primary malignancies accounts for the majority of metastatic brain tumors:

    1. lung, breast, melanoma
    2. testis, ovary, melanoma
    3. lung, prostate, uterus
    4. pancreas, melanoma, ovary
    5. salivary gland, ovary, testis

9). CNS tumors which commonly present clinically with tinnitus and hearing loss include:

    1. meningioma
    2. metastatic carcinoma
    3. ganglioneuroma
    4. schwannoma
    5. ependymoma

(10-13) Match the following neoplastic processes of the central and peripheral nervous system with the following neurocutaneous syndromes.

    1. hemangioblastoma
    2. pilocytic astrocytoma
    3. meningioma
    4. cortical hamartoma
    5. plexiform neurofibromas

10). Neurofibromatosis, Type I ______

11). Neurofibromatosis, Type II ______

12). Tuberous sclerosis ______

13). von Hippel-Lindau disease ______

 

(14-19) Abnormalities of the following chromosomes are associated with these disease processes. Answers may be used more than once.

  1. 22
  2. 17
  3. 3
  4. 9

14). von Hippel-Lindau disease ______

15). Meningioma ______

16). Tuberous sclerosis ______

17). Neurofibromatosis, Type I ______

18). Neurofibromatosis, Type II ______

19). Medulloblastoma _____

 

  1. The following is the most common primary intracranial tumor in adults:
    1. meningioma
    2. ependymoma
    3. pineoblastoma
    4. astrocytoma
    5. glioblastoma multiforme

21). The following CNS tumor has a peak incidence in the first decade of life and is usually located in the cerebellum:

    1. pineoblastoma
    2. pleomorphic xanthoastrocytoma
    3. medulloblastoma
    4. gemistocytic astrocytoma
    5. meningioma

     

22).The following tumor may cause seizures secondary to compression and tends to erode adjacent bone:
  1. pilocytic astrocytoma
  2. meningioma
  3. ependymoma
  4. medulloblastoma
  5. oligodendroglioma

23).The following statement(s) is/are true regarding Schwannomas:

    1. Usually are circumscribed.
    2. Can arise from small and large nerves.
    3. A component of neurofibromatosis, Type II.
    4. May be multiple or single.
    5. All of the above.

24). The following statement(s) is/are true regarding neurofibromas:

    1. Are not well circumscribed and tend to merge with surrounding tissue.
    2. Plexiforme type is a component of neurofibromatosis Type I.
    3. May be multiple or single.
    4. May undergo malignant degeneration in a patient with neurofibromatosis, Type I.
    5. All of the above.

 

25). The following CNS tumors contains tumor cell rosettes as a typical histologic feature:

    1. pilocytic astrocytoma
    2. ependymoma
    3. glioblastoma multiforme
    4. meningioma
    5. oligodendroglioma

 

26). The following statements is/are true regarding oligodendroglioma:

    1. Account for less than 15% of gliomas.
    2. Usually a slow growing tumor, clinically produces seizures, and has a better prognosis than astrocytomas.
    3. May be circumscribed and usually contains calcifications.
    4. Has a predilection for white matter and histologically tumor cells have a "fried-egg" appearance due to nuclei surrounded by a clear cytoplasmic halo.
    5. All of the above.

27). The following tumor contains perivascular pseudorosettes:

  1. ependymoma
  2. oligodendroglioma
  3. glioblastoma multiforme
  4. meningioma
  5. pilocytic astrocytoma

 

28). This lesion may produce positional headaches, and can cause non-communicating hydrocephalus secondary to obstruction of the foramina of Monro:

    1. acoustic neuroma
    2. pilocytic astrocytoma
    3. colloid cyst
    4. hamartoma of tuberous sclerosis
    5. meningioma, papillary variant

 

(29-34) Match the following cells of origin with the list of tumors below:

    1. neural crest
    2. astrocytes
    3. primitive undifferentiated neuroectodermal cells
    4. unknown cell of origin
    5. meningothelial cells
    6. Rathke pouch remnants

29). Glioblastoma multiforme ______

30). Meningioma, secretory variant ______

31). Schwannoma ______

32). Craniopharyngioma ______

33). Hemangioblastoma ______

34). Medulloblastoma ______