MICROBIAL CARCINOGENESIS
Linkage of gastric infection with H. Pylori to causation of gastric lymphomas and carcinomas
Epidemiological studies,detection of H. Pylori in a vast majority of gastric lymphomas
Treatment with antibiotics results in regression of the lymphoma.
MALTomas(arise in mucosa -assoc. lymphoid tissue
Generation of H. Pylori-reactive T cells,activation of polyclonal B cells,proliferating B cells,accumulation of mutations,T cell independency