B-cell Lymphoma in Immuno-Suppressed Patients
AIDS or long-term immunosuppressive therapy for preventing allograft rejection-multifocal B-cell tumors within lymphoid tissue or central nervous system.
Tumors are polyclonal at the outset, but develop into monocolonal proliferations.
The growth of EBV-driven cells-sensitive to immunological regulation (tumor regresses after relaxation of immunosuppressive therapy).