PPT Slide
E7 binds non-phorylated Rb - sequestration of Rb
E6 binds p53 - degradation of p53
E6, 7 proteins from high-risk HPV (16, 18, 31) binds Rb, p53 with high affinity - immortalization
Co-transfection with mutated ras - full malignant transformation.
HPV infection act as initiation,but + other genetic events or environmental factors are needed.