Benign warts, preneoplastic lesions
Cancers: integration in host chromosomes, random but clonal.
Site of viral DNA interruption constant: E1/E2 open reading frame
Result: repression of transcription of E6 and E7 early viral genes;
over-expression of E6, 7 proteins of HPV-16, 18
Thus,the oncogenic potential of HPV 18,16 can be related to E6,E7 early gene products.