Immunotherapy of Human Tumors(what are the prospects for immunotherapy to generate anti-tumor responses?

Approach Agent Mechanisms

Systemic, active Immunoadjuvants: enhances cell-mediated

nonspecific - BCG immunity

- Mycobacteria extracts

Immunorestorative: restores immunocompetence

- Levamisole

Systemic, active - Unmodified tumor cells increases tumor-specific

specific - modified tumor antigens immune response

Local - Haptenes (DNCB) induces tumor immunity

- BCG or activates macrophages

- antibodies (monoclonal)

- anti-idiotypic antibodies

- lymphokines

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