What are the prospects for immunotherapy to generate antitumor responses?
A. Tumor cell vaccines - some patients have circulating T cells directed against their tumor cells, and in this setting the aim is to increase their frequency. Autologous or allogeneic tumor cells, x-irradiated to prevent replication in vivo, or mixed wi
B. Immunization with tumor-specific peptides - Appropriate only for those tumors for which TAA have been cloned and peptides synthesized. Thus, presently of limited value clinically as vaccines to induce anti-tumor responses.