Cellular Effectors that Mediate Immunity (cont.)
3. Macrophages-activated exhibit selective cytotoxicity against tumor cells.
NK cells collaborate in anti-tumor reactivity
(e.g. INF-_ secreted by T and NK cells, activator of macrophages). Kill by production of reactive oxygen , or secretion of TNF-a.
4. Humoral mechanisms activation of complement
induction of ADCC by NK cells