Graveís Disease
End-organ effects of an excess of thyroid hormone
Excess production of thyroid hormone
Most common cause of hyperthyroidism (70-90% cases)
Female-dominant autoimmune disease (20-40y of age)
Association with HLA-DR3 positivity
Presence of TSI-thyroid stimulating immunoglobulin (owing to a defect in suppressor T-cells, B-cells synthesize this antibody against the TSH receptor.
Association with viral illness