Causes for Increased Thyroxine-Binding Globulin

I. Increased TBG

A. Increased estrogens

1. Pregnancy

2. Oral contraceptives

3. Estrogen therapy

B. Other medications

1. Perphenazine (Trilafon) occasionally

2. Heroin and methadone (variable degree)

C. Severe liver disease

1. Severe acute hepatitis

2. Severe cirrhosis (occasionally)

D. Congenital

E. Acute intermittent porphyria

F. Human immunodeficiency virus (HIV) infection

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