Synthesis of Thyroid Hormones

• The predominant hormone initially released from the thyroid gland - T4. It is peripherally converted to T3 - which is the metabolically active hormone.

T4 T3 T4 rT3 (inactive)

deiodinase deiodinase

(outer ring) (inner ring)

blocked rT3

acute, chronic disease Euthyroid sick

Syndrome

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