Acquired Hyperbilirubinemia (cont.)

Conjugated (CB) hyperbilirubinemia: intrahepatic CB fractionation > 50%

Conjugated (CB) hyperbilirubinemia: extrahepatic (common bile duct/ampulla of Vater) CB fractionation > 50%

Chronic liver disease

Defects in hepatocyte or canalicular transport system

Viral hepatitis

Cystic fibrosis

Benign cholestasis of pregnancy

Use of drugs

Defects in interlobular/septal bile ducts

Intrahepatic biliary atresia

Primary biliary cirrhosis

Primary sclerosing cholangitis

Extrahepatic biliary atresia

Stone in the common bile duct

Gallbladder cancer

Cholangiocarcinoma

Carcinoma of the common bile duct/ampulla of Vater

Carcinoma of head of pancreas

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