Acquired Hyperbilirubinemia

Unconjugated (UCB) hyperbilirubinemia: CB fractionation > 20%

Increased production

Impaired uptake

Impaired conjugation

Extravascular hemolytic anemias: autoimmune hemolytic anemias (SLE, drugs).

Ineffective erythropoiesis: B12 and folate deficiency.

Use of drugs: rifampin, radiographic contrast dyes.

Physiologic jaundice of newborn

Viral hepatitis

Chronic liver disease

Portacaval shunt

Physiologic jaundice of newborn

ABO incompatibility

Breast milk jaundice

Viral hepatitis

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