The process of grading and staging of cancer is an attempt to estimate the aggressiveness or degree of malignancy of a cancer.
Which one of the following statements is correct?
| A. | Grading of cancer has greater clinical value. |
| B. | Staging is based on the cytologic differentiation of tumor cells and the number of mitoses within the tumor. |
| C. | Staging is based on the size of the primary lesion, its extent of spread to regional lymph nodes, and the presence or absence of metastases. |
| D. | Grading is based on the degree of local invasion of the primary tumor. |