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Answer to Question 3

A. Metastatic cancer

Question 4

A 79 year old man was admitted to the hospital with complaint of suprapubic pain associated with hematuria. Workup for hematuria was pursued. Urine analysis showed numerous red blood cells, many neutrophils and bacteria. Urine cytology showed hyperchromatic neoplastic cells consistent with transitional cell carcinoma. Subsequent bladder biopsy showed a high grade transitional cell carcinoma.

All of the following statements about the above neoplasm are correct EXCEPT:
A.It has been associated with p53 gene mutation.
B.It arises only in the bladder.
C.It is regarded as clonal in nature.
D.It has been etiologically associated with cigarette smoking.