Table 1

Clinico-pathologic Classification

in Renal Syndromes


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H = High frequency among patients with the syndrome

L = Low frequency among patients with the syndrome

1.

Nephrotic Syndrome (NS)

Primary Nephrotic Syndrome

  • Minimal change disease - H
  • Focal segmental glomerulosclerosis - H
  • Membranous glomerulopathy - L

Systemic Nephrotic Syndrome

  • Diabetes mellitus - H
  • Amyloidosis - L
  • Systemic lupus erythematosus (WHO Class V)

2A.

Nephritic Syndrome - Low Serum Complement

Primary Nephritic Syndrome

  • Post-infectious glomerulonephritis (GN)
  • Membranoproliferative GN - L

Systemic Nephritic Syndrome

  • Systemic lupus erythematosus (WHO Class III, WHO Class IV) - H
  • Infectious endocarditis
  • HCV-associated cryoglobulinemia

2B.

Nephritic Syndrome - Normal Serum Complement

Primary Nephritic Syndrome

  • IgA Nephropathy
  • Hereditary Nephritis (Alport syndrome) - L
  • Rapidly progressive GN (RPGN), ANCA associated, pauci-immune

Systemic Nephritic Syndrome

  • Lupus nephritis (WHO Class II) - H
  • Anti-basement membrane disease (Goodpasture's Syndrome) - L
  • Systemic vasculitis:
    • Polyarteritis nodosa
    • microscopic polyarteritis
    • Wegener's granulomatosis
    • Henoch Schoenlein Purpura
  • Thrombotic thrombocytopenic purpura / Hemolytic uremic syndrome

3.

Acute Renal Failure

  • Pre Renal - Decreased renal perfusion

  • Renal

    • Rapidly progressive GN (RPGN)
      • Pauci-immune RPGN, ANCA-associated
      • Anti-glomerular basement membrane disease (Goodpasture) - L
      • Immune complex mediated RPGN:Systemic lupus erythematosus, IgANephropathy, etc.
    • Acute tubulointerstitial diseases:
      • Acute tubular necrosis (ATN) - H
      • Acute interstitial nephritis (AIN) - H

  • Post Renal - Obstruction

4.

Chronic renal failure

H = High frequency among patients with the syndrome

L = Low frequency among patients with the syndrome