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S6C34aP28a-1: To the right in this lesion of epidermolysis bullosa acquisita (EBA), the epidermis has separated from the dermis; the defect is sub-epidermal. The lesion is cell-poor at the dermal-epidermal interface and in the perivascular spaces. The papillary dermis to the left is either edematous or shows fibrolysis (pale and fiber-poor).

S6C34aP28a-2: At the margin of this subepidermal bulla (EBA), basal keratinocytes, that have separated from the dermis, show cytopathic changes. Coagulated cytoplasmic debris has collected in the defect in an area in which the basal layer is disorganized. The basal keratinocytes show nuclear disarray and increased cytoplasmic acidophilia. A dermal papilla is preserved along the floor of the defect on the left. Fibrin is irregularly condensed along the surface of the floor of the defect. Two melanophages are present in the dermis.

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