S6C34P28-EBullosa  Acquisita

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S6C34P28-1: With a Pas-hematoxylin stain, the basement membrane is thickened, disrupted, convoluted, and reduplicated along the floor of the defect. Condensed fibrin in the defect is PAS+ (EBA).

S6C34P28-2: The basement membrane is thickened and discontinuous along the floor of the defect (red arrows) (EBA).

S6C34P28-3: This lesion of EBA is late in its evolution; epidermis has partially regenerated along the floor from the right to the left (the epidermis along the floor has a greater vertical dimension on the right than on the left). In the region of the green arrows, the regenerating epithelium has separated from the dermis (the insult has been repeated). Fibrin forms a mesh within the defect. The roof along the surface is necrotic. There are cytopathic changes in the epidermis.

S6C34P28-5: In this area of a lesion of EBA, the defect contains condensed fibrin with a loose infiltrate of lymphoid cells. Fibrotic dermal papillae project into the defect.

S6C34P28-6: With an immunohistochemical reaction for IgG, there are positive deposits at the dermal-epidermal interface and in the walls of vessels (EBA). Focally, to the right of the field, there is a suggestion of partial lysis of both the basement membrane and the connective tissue of the subjacent papillary dermis.

 

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