S9C25aaaP16aaa-Macular Atrophy-Anetoderma

S9C25aaaP16aaa-1: With a Verhoeff van Giesen stain for connective tissue, a few coarse elastic fibers are present in the reticular dermis near the interface with the papillary dermis. In this field at this magnification, the remainder of the dermis is relatively devoid of elastica. Wide spacing of collagen bundles is again a feature (elastolysis; macular atrophy).

S9C25aaaP16aaa-2: At a higher magnification, the spaces among collagen bundles of the reticular dermis contain delicate, lightly stained elastic fibers; these are partially digested fibers. Alternately, some of the fibers may represent regeneration. A few clusters of elastic fibers, near the bottom of the field on the right, are associated with a few histiocytes and giant cells. On this basis, the patterns might be characterized as late in their evolution; the few histiocytic cells might be offered as evidence that the elastolysis has been mediated at a cellular level.

S9C25aaaP16aaa-3: At one margin of the biopsy specimen (i.e., to the right), elastic fibers, some of which are more normal in character, are partially preserved in the upper portion of the reticular dermis. The delicate, arborizing fibers of the papillary dermis are also represented. The patterns serve as a control for the patterns in the central portion of this lesion (elastolysis).

 

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