S13C6P4-Congenital Histiocytosis

S13C6P4-1: This is an additional example of congenital regressing histiocytosis. There is a superficial zone of necrosis that is somewhat saucer-shaped. The thin epidermis is outlined in ghost arrays along the surface of the zone of necrosis. The zone of necrosis in the dermis contains extravasated red blood cells (light orange zone to the right of the center of the field). Infiltrates of inflammatory cells have collected in a band-like pattern at the interface between the viable and the necrotic tissue. In the viable portion of the reticular dermis to the right of the center of the field, there are interstitial and perivascular infiltrates of cells (histiocytes).

S13C6P4-2: In this field, the pattern is representative of the reticular dermis to the right of the center of the field in as seen in S13C3P3-1; there are diffuse, interstitial infiltrates of rather bland histiocytes with spotty mixed infiltrates of lymphocytes and histiocytes.

S13C6P4-3: The chromatin of the nuclei of the histiocytes is delicate. Many of the nuclei of these distinctive cells are grooved or notched (congenital regressing histiocytosis).

 

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