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S13C5P3-1: The lesions of regressing congenital histiocytosis
share many features with those of classic histiocytosis X. As in classic histiocytosis X, the infiltrates may be focally, or diffusely, band-like in the upper portion of the dermis, particularly the papillary dermis. A distinction between the regressing disorder and classic histiocytosis X may be difficult to define histologically. Inflammatory crusts, as seen in this example of congenital regressing histiocytosis, seem to be a common feature of the regressing variant. The infiltrates often are cytologically bland, but this feature is of too subjective a nature to be of use in making a distinction. The distinctions are primarily based on clinical findings and observations. Age at the onset of the disorder is important; a history of regressing lesions is important. Blue arrows identify loose infiltrates of distinctive histiocytes in a widened papillary dermis. The eroded area to the right is seen at higher magnification in the next photo.
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