|
S6C13P7-3: At higher magnification, acantholysis is evident by the loss of intercellular bridges, by the rounded contours of individual keratinocytes, and by dyskeratosis. Condensed, acidophilic cytoplasm of
keratinocytes is a feature of the cells of the basal unit and of cells in the confluent defect. Green arrows identify two acantholytic, dyskeratotic cells. Although the cleft is in the superficial unit near the
intermediate zone, there are cytologic features in keeping with a process affecting cells of the basal unit, including the basal layer. In the basal unit, the cells are not joined together by intercellular bridges
(familial pemphigus-like, basal unit acantholytic disease [Hailey-Hailey disease]).
|
