S5C26P19-Erythema Annulare 
Centrifugum

S5C26P19-1: The epidermis is slightly hyperplastic (acanthotic); it shows mild papillomatosis  and mild hyperkeratosis. The papillary dermis is widened and fibrotic. Perivenular infiltrates are prominent in the upper portion of the reticular dermis. Mild infiltrates extend along vessels into the dermal papillae (EAC, superficial pattern).

S5C26P19-2: Lesion of EAC showing pattern of lymphocytic infiltrate of dermis in this field.

S5C26P19-3: In this area, the patterns, in the basal unit of the epidermis, are spongiotic. The tendency for the infiltrates to be concentrated in the basal unit near the basement membrane area lends a lichenoid quality to the reaction. Again, as in some other lesions, the distinctions between spongiosis and a lichenoid reaction are arbitrary (EAC, superficial pattern).

S5C26P219-4: The clinical appearance of a lesion of EAC ( a disorder in the category of the lymphocytic infiltrates of the dermis) is represented.  The biopsy specimen from the lesion shows the patterns seen in S5C27P20-1 & 2.

S5C26P19-5: The pattern in this lesion of EAC is spongiotic vesicular and psoriasiform. The dermal infiltrates are limited to the superficial portion of the dermis (i.e., superficial pattern of EAC). This pattern may be simply a zonal variation within a lesion; it may be related to the site selected for biopsy. Perhaps, it is a pattern most likely encountered at the active margin of such a lesion.

S5C26P19-6: The epidermis shows psoriasiform and spongiotic patterns with inter- and intra-cellular edema. Focally, lymphocytes have migrated into the epidermis in the areas of edema. Infiltrates are perivenular in the upper 1/3 of the reticular dermis (EAC, superficial pattern).

 

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