S5C25P18LymphocyticInfiltrate

S5C25P18-2: At a higher magnification, the perivascular infiltrates are dense and, at this magnification, appear to be monotonous. Lymphocytic lymphoma/leukemia must be considered in the differential diagnosis.

S5C25P18-3: The infiltrates are dense and rather monotonous. In the area outlined by blue arrows, there is a cluster of large (transformed) lymphoid cells. There is a mild dermal mucinosis. For some observers, a lymphocytic infiltrate with mucinous changes is likely to evoke the virtual images of collagen-vascular disease.


S5C25P18-1: This is a most striking example of a lymphocytic infiltrate of the dermis. The dense perifollicular component in large part is a reflection of the rich blood supply of the perifollicular connective sheath (“lymphocytic infiltrate of Jessner” by clinical criteria).

S5C25P18-4: The larger lymphoid cells in a cluster have delicate chromatin patterns and a thin rim of pale cytoplasm; they are transformed lymphoid cells. The cluster of large cells is not a regular feature of the common lymphocytic infiltrates of the dermis.

S5C25P18-5: In this field, two of the large cells have immunoblastic qualities. The clinical impression was “lymphocytic infiltrate of Jessner.” Five years after the first (biopsy proven) diagnosis of lymphocytic infiltrate of Jessner, the patient developed a subcutaneous tumor; an histologic examination of a biopsy specimen, showed the pattern of a large cell malignant lymphoma.

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