S5C14P8-DLE-misc



S5C14P8-1: Another example of hypertrophic LE shows the extremities of columns of hyperplastic squamous cells extending into the upper portion of the reticular dermis. The nests break into the dermis without inducing a tumor, or reactive, stroma. In the process, connective tissue fibers are likely to be entrapped in the interstitium of the infiltrating epithelium (i.e., pseudoepitheliomatous hyperplasia) (S5C19VA2-2). The angulated configuration of the nests at their deep extremities is a feature commonly seen in areas of infiltrating squamous epithelium, including both pseudoepitheliomatous hyperplasias and carcinomas.

S5C14P8-2: Senescent lichenoid reaction of LE with cytolytic changes affecting the basal layer of sweat ducts. The adjacent dermis is fibrotic; it shows mild interstitial infiltrates of lymphoid cells.

S5C14P8-3: At a higher magnification, the epidermal changes are characteristic; there is basement membrane hyalinosis. Cytolytic changes have damaged a sweat duct in the upper portion of the dermis. Vessels are ectatic.

S5C14P8-4: Atrophic LE with papillary dermal fibrosis. The changes to the right in the reticular dermis represent a zone of mucinosis, even though this H&E stain does not demonstrate mucinous material.

S5C14P8-5: The epidermis is atrophic; the basement membrane is not significantly altered (LE). A comparable pattern could also be seen in a lesion of dermatomyositis.

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