S4C9P3Lues

2nd LUES (continued, #2)

S4C9P3-1: The infiltrate of this perivascular space is granulomatous. Epithelioid histiocytes are clustered in granulomatous patterns; there is a solitary giant cell. Granulomas of this type are occasionally a feature of secondary lues.


S4C9P3-2: In this lesion of tertiary lues, zones of both fibrosis and necrosis in the reticular dermis are partially outlined by clusters, and traceries, of epithelioid histiocytes and giant cells.

S4C9P3-3: This perianal lesion is verrucoid; hyperplasia of squamous epithelium has produced elongation of the rete ridges, but there is no evidence of invasion of the reticular dermis in patterns of pseudoepitheliomatous hyperplasia. Infiltrates of inflammatory cells hug the epithelium ( condyloma latum).

S4C9P3-4: Inflammatory cells have migrated into the epithelium among keratinocytes. Focally, they have collected in angulated and rounded defects in the superficial unit of the epidermis. The changes are not koilocytotic; they are spongioform and pustular (condyloma latum).

S4C9P3-5: Many of the cells of the epidermal infiltrates are neutrophils. Neutrophils in lytic defects among keratinocytes, as seen in this field, qualify the pattern as representing a variant of spongioform pustule (condyloma latum).

S4C9P3-6: The epidermis in this field from a lesion of secondary lues shows a spongioform pustular pattern. The pattern, in this field, might be characterized as a result of the migration of inflammatory cells from a vessel in a dermal papilla (pattern of the so-called “squirting papilla” ). Lymphocytes, neutrophils, and histiocytes have collected at the dermal-epidermal interface.

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