S1C17P7-Cell Types-Lues Histiocytes and Plasma Cells

S1C17P7-1: At the lower left corner, a portion of a dermal papilla is represented. Epidermis occupies the remainder of the field. The basal layer shows vacuolar changes; a green arrow identified a necrotic keratinocyte. The epidermis above the basal layer shows the cytologic features of cells of a hyperplastic superficial unit. There is no recognizable basal unit. This deficiency and the combination of other features contribute lichenoid qualities to the pattern. This is the uncommon pattern of secondary lues in which the changes are more lichenoid than pityriasic. The distinctive cells (red arrows) with scanty cytoplasm and elongated, irregular nuclei are migratory histiocytes.

S1C17P7-2: A bit of epidermis is represented in the upper, right portion of the field. The remainder of the field is papillary dermis. The dermal infiltrate, in this lesion of secondary lues, shows two characteristic features; there is a high component of migratory histiocytes (red arrows), and there is a component of plasma cells and plasmacytoid cells (lavender arrows).

S1C17P7-3: In some lesions of secondary lues, the dermal infiltrates are rich in plasma cells.

S1C17P7-4: Plasma cells and migratory histiocytes are prominent in the infiltrates in this example of secondary lues.

S1C17P7-5: With a slightly different technique in this lesion of secondary lues, the lavender cytoplasm of plasma cells is accentuated. Some of the cells have a hof (a cytoplasmic property that corresponds to the golgi apparatus). Plasma cells are rich in cytoplasmic components that are required for the formation of protein (i.e., ribonucleic acids). Cells with lavender cytoplasm might be thought of factories for the production of proteinaceous products; for plasma cells the products are antibodies.

 

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