S15C6P9 Lymphomatoid Granulomatosis
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S15C6P9-1: The infiltrates are loosely tumoral. There is nuclear pleomorphism with cytologic atypia. Focally, alveolar walls are intact, but infiltrated.

S15C6P9-2: Atypical lymphoid cells are arranged in an angiocentric pattern. Some of the cells have collected in the sub-endothelial space.

S15C6P9-3: Atypical lymphoid cells have infiltrated the thin muscular wall of this vessel. There are fragments of nuclear debris.

S15C6P9-4: Atypical cells have infiltrated alveolar walls and have collected in alveolar spaces in association with a fibrinous exudate.

S15C6P9-5: To the left of the central cleft, the atypical cells have infiltrated peri-adrenal fat; lipocytes are entrapped. To the right of the cleft, necrotic adrenal cortex is represented. Focally, the infiltrate is preserved in the adrenal cortex.

S15C6P9-6: Currently, lymphomatoid granulomatosis is characterized as a lymphoproliferative disorder; often, the disease is EB virus-related. In this field, scattered adrenal cells show cytomegaly, a feature of cytomegalic virus infection.

 

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