S15C6P8 LGranulomatosis



S15C6P8-1: In this field, the lesion takes on qualities of a “lymphocytic pneumonitis” of the lung. The infiltrates are atypical, even at this magnification. Atypical lymphoid cells are present in the lumen of a muscular vessel. Some of the alveoli contain mucinous material.

S15C6P8-2: The interstitial infiltrates of lymphoid cells show cytologic atypia with variations in nuclear size and outline. Centrally, there are fibrin deposits in the alveoli.

S15C6P8-3: In this field, the lesion shows extensive necrosis (“granulomatosis”). A vessel, to the left of the center of the field, shows fibrinoid necrosis; the lesion has angiocentric qualities; it is vasculo-necrotic. The surviving lymphoid cells are atypical; the significance of cytologic atypia in the face of extensive necrosis is questionable.

S15C6P8-4: Atypical lymphoid cells are present in the lumen of this thin-walled pulmonary vessel.

S15C6P8-5: The interstitial infiltrates are atypical.Lymphoid cells have enlarged nuclei; the nuclei vary somewhat in size, staining, and outline.

S15C6P8-6:Compare the patterns in this field with those of fig. S15C6P8-3. They are remarkably similar, with the exception of the extensive necrosis as seen in fig. 3. A vasocentric component is apparent to the left of the center of the field. The angiocentricity can be cited as a feature that predisposes to necrosis. The infiltrates are tumorous and atypical.

S15C6P8-7: Nuclear atypia and pleomorphism are features in this field. There are scattered fragments of nuclear debris.

S15C6P8-8: In the absence of clinicopathologic correlations, the patterns in this field would qualify as a large cell lymphoma (angiocentric variant).

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