S15C2P3-Atypical Histiocytoma



S15C2P3-1: This is a lesion from the scalp of a 3 year old boy. The lesion is diffuse in the upper 1/3 of the dermis. Collagen bundles of the reticular dermis are preserved among nests of cells in the lower portion of the field. The lesion presses upon the epidermis. A follicle is preserved within the lesion.

S15C2P3-2:The infiltrate of histiocytes extend to the dermal-epidermal interface. Rete patterns are partially effaced. There are loose infiltrates of lymphocytes, among the histiocytes, on the right side of the field.

S15C2P3-3: In this field, some of the histiocytes have enlarged nuclei; some of these cells have cleaved nuclei (green arrows). The cleaved nuclei resemble the nuclei of histiocytes in the infiltrates of histiocytosis X.

S15C2P3-4: There are scattered multinucleated giant cells (green arrows). Cells are loosely spaced in a fibrous matrix. There are loose infiltrates of lymphoid cells.

S15C2P3-5: Histiocytes are loosely spaced in a fibrous matrix. One giant cell has features of a touton type cell, but each of its nuclei is deeply grooved (atypical histiocytoma or atypical xanthogranuloma). This sequence is continued on the next page (click navigation bar,“next page in sequence,” below).

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