S15C2P2-Xanthogranuloma?


S15C2P2-1: This lesion was in the files as an example of juvenile xanthogranuloma. It is circumscribed in the dermis and spares the epidermis. Cellularity is variable; in areas, the cells form nests that are loosely spaced in a delicate fibrous matrix. Near the bottom of the field, the infiltrates are more diffuse. There are scattered giant cells some of which are of the touton type.

S15C2P1-2: The lesion bulges into the subcutaneous fat. Some examples of juvenile xanthogranuloma will extend into the fat and may even invade skeletal muscle. Often, the cells of a lesion of juvenile xanthogranuloma are more spindle shaped in the deeper portions; this example is no exception.

S15C2P2-3: Pale histiocytes are closely spaced. Nuclei vary in outlines and have delicate chromatin. Centrally, the giant cell has its nuclei in a ring-like pattern.

S15C2P2-4: Some of the histiocytes show zones of cytoplasmic basophilia (green arrows). Some of the nuclei are indented or cleaved. The cytoplasmic basophilia is a feature seen in some examples of reticulohistiocytoma. Either the basophilia has no value as a discriminating feature, or this is reticulohistiocytoma. The overall patterns are more in keeping with juvenile xanthogranuloma.

S15C2P2-5: With a different technique, some of the cells show zones of cytoplasmic basophilia (green arrows).

NEXT PAGE in spatial sequence along horizontal axis of tier


Beige BARS to right provide access to CHAPTERS of this SECTION. Mauve bars provide access to other SECTIONS on this SITE.

BACK a PAGE in spatial sequence along horizontal axis of tier