S13C23P21-1: This is an example of epidermodysplasia verruciformis in association with HIV infection. The normal epidermis is to the right. To the left beyond the follicular ostium, the hyperplastic epidermis shows distinctive changes of a type commonly seen in the setting of epidermodysplasia verriciformis. There is hypertrophy of keratinocytes of the superficial unit of the epidermis. These cells have more abundant cytoplasm and an enlarged nucleus with one or more nucleoli. The basal unit is slightly hyperplastic, but cells of the basal unit individually are not significantly enlarged.

S13C23P21-2: At higher magnification, two populations of cells are represented in the superficial unit of the epidermis. Large swollen cells have faintly basophilic cytoplasm with large nuclei and prominent nucleoli. In some of the nuclei, pale, globular deposits have pushed the nuclear chromatin aside. I would interpret these acidophilic, globular deposits as intranuclear inclusions. Smaller  keratinocytes, that are more intensely eosinophilic, are compressed among the collections of large, basophilic cells. The basal unit shows some degree of nuclear disarray.

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