S13C22P20-Systemic Mast Cell Disease

S13C22P20-1: To the right and below the center of this field, in a bone marrow biopsy specimen, a population of pale spindle cells forms a sheet. Eosinophils are sprinkled among the spindle cells. Spicules of cancellous bone outline the area. Above the sheet, there is a lymphoid nodule with scattered collections of large, pale lymphoid cells. The lymphoid infiltrates have partially eroded the bone spicule to the left; other bone spicules are scalloped along their margins (systemic mastocytosis).

S13C22P20-2: The mast cells, in sheet-like patterns, are spindle-shaped. They have pale, faintly lavender cytoplasm and elongated nuclei with uniformly distributed chromatin. Eosinophils are sprinkled among the mast cells.

S13C22P20-3: The mast cells have uniformly distributed chromatin. The patterns, in which spindle cells are closely aggregated, provide an epithelioid quality.

S13C22P20-4: Green arrows identify dendritic mast cells. The changes in the adjacent marrow were interpreted as dysmyelopoiesis. The associations might be interpreted as evidence that the mast cell infiltrate is also neoplastic.

 

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