S13C14aP12aKaposi'sDisease



S13C14aP12a-1: A lesion of acral skin is represented. It is slightly polypoid at the surface with a collarette of epidermis at the margin; rete patterns over the tumor are effaced. A nodular tumor of the dermis is outlined by a condensation of inflamed fibrous tissue. The lesion is irregularly partitioned by fibrous membranes. Dilated vessels partially outline, and extend into, the tumor. To the right, some of the dilated vessels are congested. The lesion is solid and cellular.

S13C14aP12a-2: In the areas outlined by green arrows, dilated, congested vessels are closely clustered. In the neighboring cellular portions, small slit-like spaces contain red blood cells ( Kaposi’s disease, solid variant with focal angiomatous patterns).

S13C14aP12a-3: The basic pattern is that of a solid tumor composed of spindle cells. The cells have scanty cytoplasm. The nuclei of the spindle cells, being closely spaced, contribute a prominent basophilia. The angiomatous component is outlined by green arrows.

S13C14aP12a-4: In this example of Kaposi’s disease (solid variant), the cells have a moderate amount of pale, amphophilic cytoplasm. Slit-like spaces among the spindle cells contain red blood cells. Nuclei are round or oval; they have delicate chromatin patterns. Nuclear characteristics are uniform.

S13C14aP12a-5: In this field, the cells are arranged in interlacing fascicles. Nuclei are thin and elongated. Slit-like spaces, containing red blood cells, are not a prominent feature. There are spotty infiltrates of lymphoid cells. The pattern is that of the solid variant; it is sarcomatous.

S13C14aP12a-6: There is some evidence of angiomatous transformation in this field. A green arrow identifies a mitotic figure. Blue arrows identify a small cluster of acidophilic droplets. These droplets are common in lesions of Kaposi’s disease, particularly in lesions showing the patterns of the solid variant. The droplets are an aid in the diagnosis of Kaposi’s disease; they may represent fragments of red blood cells. Generally the small droplets are less acidophilic than the neighboring red blood cells.

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