S13C13bP11bXeroderma



S13C13bP11b-1: In the region of the green arrows, the basal layer is obscured by cytopathic changes. The basal cells show cytoplasmic acidophilia; some of the degenerating basal cells are anucleated and some have pyknotic nuclei. The basement membrane is thickened and hyalinized; the cytoplasm of the degenerating basal cells merges with the basement membrane (xeroderma pigmentosa ). There are small lytic defects at the dermal-epidermal interface (cell-poor, LE-like lichenoid reaction).

S13bC13bP11b-2: The patterns are those of a cell-poor lichenoid reaction (LE-like type). Basal keratinocytes show degenerative changes with coagulation of the cytoplasm, and pyknosis and lysis of nuclei. There are vacuolar changes. There are focal lytic defects at the dermal-epidermal interface. The papillary dermis is fibrotic. To the left, at the dermal-epidermal interface, there is a junctional nest of atypical melanocytes .

S13C13bP11b-3: A component of the basal unit is preserved in the region of the green arrows. The neighboring epidermis shows degenerative changes, particularly at the level of the basal layer. The basement membrane is thickened (red arrows). There is a small lytic defect at the dermal-epidermal interface; a cleft extends from the defect into the overlying epidermis; in the region of the defect, a basal layer has partially reformed along the superior surface of the defect. Cells beneath the new basal layer show increased cytoplasmic acidophilia.

S13C13bP11b-4: Cells of the basal unit are in disarray. There are vacuolar changes at the dermal-epidermal interface. An occasional colloid body is present in the upper portion of the dermis (left margin of the field).

S13C13bP11b-5: An immunoreaction for Melan A highlights the lentiginous melanocytic hyperplasia. The hyperplasia is irregular in distribution. Focally, the lentiginous patterns are interrupted; the interruptions are more prominent in the areas showing the lichenoid reaction (centrally and to the right).

S13C13bP11b-6: Melanocytes are individually enlarged; they have prominent dendritic processes that extend into the overlying epidermis. The lichenoid reaction is prominent to the right; to the left, the basal unit is partially preserved.

S13C13bP11b-7: Melanocytes are enlarged; some appear to be multinucleated. Not all of the “clear cells” of the basal layer of the epidermis are immunoreactive (Melan A).

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