S12C21P11-1: Infiltrates of cells are distributed in layers throughout the reticular dermis; they are band-like at the interface between the papillary dermis and the reticular dermis. At the lower margin of the dermis, infiltrates are nodular. They extend into the fat to entrap lipocytes (necrobiotic xanthogranuloma).

S12C21P11-3: Interstitial infiltrates of histiocytes are loose, but diffuse, in this field. Giant cells show the nuclear arrangements of touton giant cells.

S12C21P11-4: In the interstitial infiltrates, some of the histiocytes and some of the giant cells have foamy cytoplasm (a xanthomatous quality). In the giant cells, the lipid deposits (i.e., cytoplasmic vacuoles) are prominent at the periphery of the cytoplasm; the features features are those of touton giant cells.

S12C21P11-5: Some of the nuclei are notched, but the nuclear characteristics are different from those of the cells of histiocytosis X.

S12C21P11-6: In this portion of the subcutaneous infiltrate, the giant cell, just below the center of the field, shows the characteristic features of a touton giant cell (necrobiotic xanthogranuloma).