S12C16P6-Granulomas-misc



S12C16P6-1: In this lymph nodal lesion of sinus-histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease), sinus histiocytes are hyperplastic; they are enlarged and have plump nuclei with prominent nucleoli. The histiocytes have pale, acidophilic cytoplasm. Lymphocytes are sprinkled among the distinctive histiocytes. The neighboring medullary cords contain a high component of plasma cells.

S12C16P6-2: In this tattoo, the foreign pigment is clustered (blue arrows); it appears to be intra-cellular. The lesion is not granulomatous in this example but, for some pigments, that are introduced into the dermis during the process of tattooing, the reaction can be granulomatous.


S12C16P6-3: Some of the pigments (green arrows - red deposits) used in tattoos are birefringent. The colors of the pigment, when examined under polarized light, may provide a clue as to its nature.

S12C16P6-4: The pigment deposits in this tattoo are associated with mild inflammatory infiltrates. The papillary dermis and the upper portion of the reticular dermis are fibrotic.

S12C16P6-5: The pigment deposits in this tattoo are associated with mild infiltrates of histiocytes, neutrophils, and eosinophils. In the center of the field, the reaction has an ill-defined granulomatous quality.

S12C16P6-6: With polarized light, the pigment in this area of a tattoo is orange.

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