S11C22P17-Infections, misc.

S11C22P17-1: The pattern might be characterized as having features of a “stellate abscess;” a central defect is somewhat stellate in outline. The defect contains infiltrates of inflammatory cells with a zone of condensed fibrin (to the left). The defect is outlined by palisades of histiocytes with scattered giant cells ( protothecosis).

S11C22P17-2: In this field, organisms are present among, and within the cytoplasm of, activated histiocytes. The organisms of this algae infection reproduce by the process of endosporulation. Blue arrows identify clusters of endospores; they are fairly uniform in size in each collection. They often are molded against their neighbors (PAS stain with hematoxylin counterstain) (protothecosis).

S11C22P17-3: There are diffuse infiltrates of inflammatory cells among lipocytes in the subcutaneous fat (mucormycosis).

S11C22P17-4: The interstitial infiltrates are composed of sheets of activated histiocytes with a sprinkling of inflammatory cells. Blue arrows point to hyphae; the hyphae have an affinity for hematoxylin (the walls of the hyphae are basophilic). The cluster of blue arrows at the bottom of the field point to a characteristic broad, branching hypha; there are bulbous expansions along the length of the hypha (mucormycosis).

S11C22P17-5: Broad, branching, basophilic hyphae (small arrows) extend into a defect containing loosely clustered neutrophils. The neighboring infiltrate is composed of activated histiocytes. The hyphae are non-septate; they characteristically show irregular, bulbous expansions (mucormycosis).

S11C22P17-6: Amebae (small blue arrows) are loosely spaced in a loose fibrous matrix containing infiltrates of lymphocytes and histiocytes. The organisms have a single, eccentric nucleus (a feature of a trophozoite rather than an encysted form). The nucleus has a well-defined basophilic margin with a central, pale acidophilic nucleoplasm (amebiasis)

S11C22P17-7: Mature filariae are collected in a central defect. The organisms are embedded in organizing, inflamed granulation tissue (onchocerchoma).

S11C22P17-8: The uterus of this gravid female contains microfilariae.

S11C22P17-9: Microfilariae are embedded in organizing fibrous tissue (onchocercoma).

 

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