S11C20aP15a-Mycetoma & Actinomycosis

S11C20aP15a-1: The tissue above the lower 1/4 of the field is granulation tissue. The two darker zones in the granulation tissue are areas of suppuration. In the zone of suppuration to the left, green arrows identify a colony of organisms. The colony is a “grain” (mycetoma).

S11C20aP15a-2: At higher magnification, the colony of organisms floats in sea of pus. The defect is outlined by organizing granulation tissue.

S11C20aP15a-3: Fungal organisms, in an acidophilic matrix, form the colony. Neutrophils are present at the periphery of the colony (mycetoma).

S11C20aP15a-4: This lesion is also composed of organizing granulation tissue. The darker area near the center of the field is an area of suppuration, as are the other similar dark areas (actinomycosis).

S11C20aP15a-5: A colony of filamentous organisms floats in a sea of pus. The organisms are delicate, basophilic filaments. The filaments, projecting into the pus at the periphery of the colony, are outlined by sheaths of fibrinoid material. In aggregate, the red spicular deposits at the periphery of the colony are evidence of the Splendore-Hoeppli phenomena; the deposits represent an immune response.

S11C20aP15a-6: Centrally, the organisms are filamentous and basophilic; Spicular, red deposits have formed at the periphery of the colonies.

S11C20aP15a-7: With a silver methamine stain, the organisms are filamentous.

 

UP TO TEXTUAL LEVEL, IF AT PICTORIAL LEVEL (3), OR TO HOME IF AT TEXTUAL LEVEL (2)

BACK IN SPATIAL SEQUENCE ALONG TIER

Beige buttons to the right are a continuation of the vertically oriented beige cluster above. The mauve buttons provide access to other SECTIONS on this site.

NEXT CHAPTER IN SEQUENCE, IF AT EITHER LEVEL 2 OR LEVEL 3