S11C12P7-3: This chancre has a granulation tissue-like stroma with dense infiltrates of lymphocytes and histiocytes.

S11C12P7-4: Vessels have thickened walls. Lymphocytes and histiocytes infiltrate the walls of the vessels. Endothelial cells are swollen.

S11C12P7-5: Lesions of secondary lues have variable lichenoid qualities. The lichenoid features may be combined with psoriasiform qualities; for such variants, the reaction patterns qualify as primary lichenoid patterns, or pityriasic qualities. The reaction may be lytic (i.e., lichenoid) at the dermal-epidermal interface, as in this example. Lesions may even show features of a cell-poor, senescent lichenoid reaction. In this example, the rete patterns are effaced  and the infiltrate hugs the epidermis. There are liquefactive changes at the dermal-epidermal interface. The infiltrate is lympho-histiocytic; the lymphocytes are loosely spaced in a background infiltrate of activated histiocytes. The red arrows identify reduplicated basement membrane material. The yellow arrows identify similar, pale membranes at a deeper level; these membranous structures (yellow arrows) probably represent remnants of the original basement membrane. The infiltrates have invaded the epidermis in increments and each progression in the lysis of cells in the epidermal domain is attended by a deposition of new basement membrane material. The point of the double green arrow is one nucleus away from a plasma cell; plasma cells and histiocytes contribute distinctiveness to the lichenoid, or pityriasic, reaction of secondary lues.

S11C12P7-6: Palmar lesions of secondary lues.