S10C12P10-Substitutive Fibrosis (morphea)

S10C12P10-1: The firbosing changes, at the interface between the reticular dermis and the subcutaneous fat in a lesion of morphea, has retinacular qualities. The fibrosis is band-like In lesions of this type, the fibrosis often extends along fibrous septa into the fat. In a sense, the fibrosing reaction qualifies as a variation of a fibrosing, septal panniculitis. In this example, the fibrosis is relatively confined to the interface between the reticular dermis and the subcutaneous fat (blue arrows) (morphea).

S10C12P10-2: The area of substitutive fibrosis as seen in S10C12P10-1 is below the plane defined by blue arrows in this field. The fibrous tissue in this late lesion of morphea is distinctive; it is tinctorially different from the collagenous matrix in the dermis above the blue arrows. The interface between the dermis and the fat is straight. At the interface, the fibrosing reaction extends a short distance into the fat among lipocytes. To the right, the fibrosing reaction extends along a septum into the fat.

S10C12P10-3: In this late lesion, the distinctive fibrous tissue is relatively acellular and hyalinized. It is poorly vascularized. The interface with the fat at the bottom of the field is straight (morphea). Lesions of morphea, with extensive septal components, qualify as morphea profundus.

 

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