S10C5aP3a-3: The epidermis is necrotic. Most of the nuclei have undergone karyolysis; some are pyknotic. In the zone between the red and blue arrows, a necrotic basal unit of the epidermis is represented. Dilated vessels in the dermis show fibrinoid necrosis and thrombosis (dermal changes of calcifying panniculitis).

S10C5aP3a-4: In this field, adipocytes are necrotic; ghost outlines are preserved, but most of the “cells” are anuclear. Small vessels among the lipocytes contain fibrin thrombi (calcifying panniculitis; “calciphylaxis”).

S10C5aP3a-5: The wall of this vessel in the subcutaneous fat is smudgy and necrotic; its lumen contains a fibrin thrombus. Some of the inflammatory cells, that are entrapped in the thrombus, show fragmentation of their nuclei.

S10C5aP3a-6: This vessel in the subcutaneous fat contains a collection of red blood cells and inflammatory cells. The wall of the vessel is partially calicified.

S10C5aP3a-7: The wall of this small vessel is calcified.

S10C5aP3a-8: In this field, elastic fibers are calcified. Some of the fibers are fractured. The patterns, in this field, are similar to those of a lesion of pseudoxanthoma elasticum (the process is calcifying panniculitis ). Calcium deposits are lavender; with an H&E stain, this is the characteristic tinctorial quality of zones of calcification. Elastic fibers have an affinity for calcium salts.