S10C4aP2aLipogranulomatousPanniculitis


S10C4aP2a-1: The patterns basically are lobular in distribution. The lobules show fibrosis and infiltrates of inflammatory cells. Clusters of lipocytes are entrapped. There are scattered collections of epithelioid histiocytes in granulomatous patterns. To the left of the center of the field, one granuloma shows prominent palisading of histiocytes in radial patterns.



S10C4aP2a-2: There are scattered granulomas. Multinucleated giant cells are numerous. The granuloma with radially arranged histiocytes shows an irregular defect centrally.

S10C4aP2a-3: In the center of the granuloma, vacuoles and membranes are combined to provide the image of a structure. Lipogranulomas which have membranous components can be misinterpreted as a granulomatous response to a parasite (i.e., pseudo-parasite of lipogranulomatous panniculitis).

S10C4aP2a-4: These two granulomas show features of membranous lipodystrophy (green arrows). To the left, the membrane bulges irregularly into the lumen; the irregularity might be mistaken for a section of a parasite.

S10C4aP2a-5: Irregular defects are surrounded by infiltrates of histiocytes. Convoluted membranes separate the histiocytes from the defects; the membrane is apparently the product of a reaction of the histiocytes to the lipid material in the defect (membranous lipodystrophy).

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