Leukocyte Alkaline-Phosphatase Stain

Normal cells (PMNs) contain the enzyme leukocyte alkaline phosphatase. (LAP). In CML the PMNs lack or contain a decreased amount of LAP (Right).

(LAP Stain x Oil)

Both peripheral blood samples shown above were stained for LAP. The sample on the left is a normal blood sample, and shows positive LAS staining. The sample on the right is from a CML patient. LAP staining is characteristically low or absent in CML.

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